The article below may contain offensive and/or incorrect content.
Objective: Nephrotic syndrome (NS) is a kidney disease known to adversely impact health-related quality of life (HRQOL). Patient-reported outcome (PRO) measures are commonly used to characterize HRQOL and the patient disease experience. This study aims to improve the interpretability and clinical utility of the Patient-Reported Outcomes Measurement Information System® (PROMIS®) by identifying distinct meaningful HRQOL profiles in children and adults with NS. Method: Patients were from 2 prospective NS cohort studies (PROMIS-II®: 121 children; NEPTUNE: 40 children and 219 adults) with data from 6 PROMIS® domains. Latent Profile Analysis was used to identify subgroups of patients based on PROMIS® score patterns. A 3-step analysis of latent profile predictors was used to determine how clinical parameters predicted HRQOL profile membership. Results: We identified 3 HRQOL profiles (Good, Average, and Poor) with strong indicators of membership classification (entropy >0.86). Complete proteinuria remission, reduction in symptoms, and shorter disease duration, were significant predictors of better HRQOL profile membership. Conclusions: Patients with NS can be classified by HRQOL into clinically meaningful categories. Integrating this approach into clinic may help in the identification of individuals with poor HRQOL will help clinicians better manage their symptoms and researchers study the causes and possible interventions for these patients. PROMIS® HRQOL profiles were reproducible in replication cohorts. (PsycINFO Database Record (c) 2019 APA, all rights reserved)





Departments
Authors
Libraries
Current Articles
- Article Correctness Is Author's Responsibility: Science News » NIMH’s Dr. Andrea Beckel-Mitchener Named Deputy Director of NIH BRAIN Initiative
- Article Correctness Is Author's Responsibility: Science News » NIMH Director’s Statement: Our Commitment to Ending Structural Racism in Biomedical Research
- Article Correctness Is Author's Responsibility: Video » Let’s Talk About Eating Disorders with NIMH Grantee Dr. Cynthia Bulik
- Article Correctness Is Author's Responsibility: Scientific Meeting » NIMH Livestream Event: Let’s Talk About Eating Disorders with NIMH Grantee Dr. Cynthia Bulik
- Article Correctness Is Author's Responsibility: Science News » New Experiences Enhance Learning by Resetting Key Brain Circuit
- Article Correctness Is Author's Responsibility: Blog Post » From Brain Mechanisms to Novel Therapies: Understanding and Treating Eating Disorders
- Article Correctness Is Author's Responsibility: Video » GREAT: Helpful Practices to Manage Stress and Anxiety
- Article Correctness Is Author's Responsibility: Video » What are the different types of clinical research?
- Article Correctness Is Author's Responsibility: Blog Post » Enhancing and maintaining a culture of inclusive excellence: The NIH Faculty Institutional Recruitment for Sustainable Transformation (FIRST) Program
- Article Correctness Is Author's Responsibility: The snowy countries losing their identity
- Article Correctness Is Author's Responsibility: Science News » Study Identifies Risk Factors for Elevated Anxiety in Young Adults During COVID-19 Pandemic
- Article Correctness Is Author's Responsibility: Keep paying attention to your kids' mental health in this pandemic
- Article Correctness Is Author's Responsibility: Video » What is an MRI?
- Article Correctness Is Author's Responsibility: Video » What is a blood draw?
- Article Correctness Is Author's Responsibility: Video » What is Clinical Research?
- Article Correctness Is Author's Responsibility: Science News » Gene Readouts Contribute To Distinctness of Mental Disorders
- Article Correctness Is Author's Responsibility: Science News » Adaptive screener may help identify youth at risk of suicide
- Article Correctness Is Author's Responsibility: How conspiracy theories undermine people’s trust in COVID-19 vaccines
- Article Correctness Is Author's Responsibility: Curing PTSD with a shot: The new treatments that are changing lives
- Article Correctness Is Author's Responsibility: Feeling disconnected from your partner?