The article below may contain offensive and/or incorrect content.
Objectives: Off periods in Parkinson's disease are associated with a worsening of nonmotor symptoms and acute psychological distress. The relationship between motor fluctuations and episodic distress in naturalistic settings remains unclear, particularly the role of individual psychological factors. This study aimed to identify those factors through real-life, real-time assessment using ecological momentary assessment (EMA). Method: Twenty participants (seven female) completed multiple brief prompted surveys over a 7-day period assessing current motor and medication state, social situation, episodic distress, and cognitive processes (rumination, symptom focus, and worry). Baseline depression and anxiety were measured using validated questionnaires, as were positive and negative beliefs and attitudes (metacognitions) regarding cognitive processes. The feasibility of EMA via smartphones was assessed at the end of the study. Results: Across participants, 496 complete data sets were collected. Generalized linear mixed-model regression analyses showed that episodic distress was predicted by a combination of cognitive processes, F(1, 483) = 41.14, p < .001, momentary motor state, F(3, 483) = 10.40, p < .001, time of day, F(1, 23) = 12.42, p = .002, and trait negative metacognitions, F(1, 6) = 7.21, p = .037). EMA was judged acceptable by the majority of participants. Conclusions: Time of day, cognitive processes, and negative metacognitions predict episodic distress independent of motor state. This indicates potential targets for nonpharmacological interventions aimed at alleviating episodic distress in patients with motor fluctuations. EMA is a feasible methodology for Parkinson's disease research and potential tool for delivering such interventions. (PsycINFO Database Record (c) 2019 APA, all rights reserved)





Departments
Authors
Libraries
Current Articles
- Article Correctness Is Author's Responsibility: Science News » NIMH Director’s Statement: Our Commitment to Ending Structural Racism in Biomedical Research
- Article Correctness Is Author's Responsibility: Video » Let’s Talk About Eating Disorders with NIMH Grantee Dr. Cynthia Bulik
- Article Correctness Is Author's Responsibility: Scientific Meeting » NIMH Livestream Event: Let’s Talk About Eating Disorders with NIMH Grantee Dr. Cynthia Bulik
- Article Correctness Is Author's Responsibility: Science News » New Experiences Enhance Learning by Resetting Key Brain Circuit
- Article Correctness Is Author's Responsibility: Blog Post » From Brain Mechanisms to Novel Therapies: Understanding and Treating Eating Disorders
- Article Correctness Is Author's Responsibility: Video » GREAT: Helpful Practices to Manage Stress and Anxiety
- Article Correctness Is Author's Responsibility: Video » What are the different types of clinical research?
- Article Correctness Is Author's Responsibility: Blog Post » Enhancing and maintaining a culture of inclusive excellence: The NIH Faculty Institutional Recruitment for Sustainable Transformation (FIRST) Program
- Article Correctness Is Author's Responsibility: The snowy countries losing their identity
- Article Correctness Is Author's Responsibility: Science News » Study Identifies Risk Factors for Elevated Anxiety in Young Adults During COVID-19 Pandemic
- Article Correctness Is Author's Responsibility: Keep paying attention to your kids' mental health in this pandemic
- Article Correctness Is Author's Responsibility: Video » What is an MRI?
- Article Correctness Is Author's Responsibility: Video » What is a blood draw?
- Article Correctness Is Author's Responsibility: Video » What is Clinical Research?
- Article Correctness Is Author's Responsibility: Science News » Gene Readouts Contribute To Distinctness of Mental Disorders
- Article Correctness Is Author's Responsibility: Science News » Adaptive screener may help identify youth at risk of suicide
- Article Correctness Is Author's Responsibility: How conspiracy theories undermine people’s trust in COVID-19 vaccines
- Article Correctness Is Author's Responsibility: Curing PTSD with a shot: The new treatments that are changing lives
- Article Correctness Is Author's Responsibility: Feeling disconnected from your partner?
- Article Correctness Is Author's Responsibility: Concept Clearance » Deciphering Neuroimmune Dysfunction in HIV Utilizing Human Cell Derived in vitro and in vivo Systems